The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.Figure 7. Percentage of Patients Reporting an Improvement in Erections. levitra prices unusual tiredness or weaknessIn the secondary analysis excluding those with major chronic diseases at baseline, 79 melanoma cases were identified among 14?912 participants. Recent sildenafil users had a significantly elevated risk of invasive melanoma (HR,?2.24; 95% CI, 1.05-4.78) (eTable 2 in the Supplement). Ever use of sildenafil was also associated with increased melanoma risk (HR.?2.77; 95% CI, 1.32-5.85).
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stomach upsetMean sildenafil plasma concentrations measured after the administration of a single oral dose of 100 mg to healthy male volunteers is depicted below: viagra for men The information contained on this web site is for your information only. You should never take a drug without a doctor's prescription. Do NOT give yourself any drug unless it has been prescribed for you by a doctor. swelling in your hands, ankles, or feet;Rare (less than 0.1%): Throat tightness, nasal edema, nasal dryness
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Effects were seen in dogs that might indicate impairment of fertility. Two subsequent clinical studies suggest that this effect is unlikely in humans, although a decrease in sperm concentration was seen in some men (see sections 5.1 and 5.3).Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease. Ask your doctor if your heart is healthy enough to handle the extra strain of having sex.
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